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Hypermethylation of secreted frizzled-related proteins predicts poor prognosis in non-M3 acute myeloid leukemia
文献类型:期刊
作者:Guo, Hong[1]  Zhang, Ting-juan[2]  Wen, Xiang-mei[3]  Zhou, Jing-dong[4]  Ma, Ji-chun[5]  An, Cui[6]  Zhang, Wei[7]  Xu, Zi-jun[8]  Lin, Jiang[9]  Qian, Jun[10]  
机构:[1]Jiangsu Univ, Affiliated Peoples Hosp, Lab Ctr, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.;Jiangsu Univ, Key Lab Precis Diag & Treatment Zhenjiang City, Zhenjiang, Jiangsu, Peoples R China.;
[2]Jiangsu Univ, Key Lab Precis Diag & Treatment Zhenjiang City, Zhenjiang, Jiangsu, Peoples R China.;Jiangsu Univ, Affiliated Peoples Hosp, Dept Hematol, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.;
[3]Jiangsu Univ, Affiliated Peoples Hosp, Lab Ctr, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.;Jiangsu Univ, Key Lab Precis Diag & Treatment Zhenjiang City, Zhenjiang, Jiangsu, Peoples R China.;
[4]Jiangsu Univ, Key Lab Precis Diag & Treatment Zhenjiang City, Zhenjiang, Jiangsu, Peoples R China.;Jiangsu Univ, Affiliated Peoples Hosp, Dept Hematol, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.;
[5]Jiangsu Univ, Affiliated Peoples Hosp, Lab Ctr, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.;Jiangsu Univ, Key Lab Precis Diag & Treatment Zhenjiang City, Zhenjiang, Jiangsu, Peoples R China.;
[6]Peoples Hosp Yu City, Dept Hematol, Dezhou, Peoples R China.;
[7]Jiangsu Univ, Key Lab Precis Diag & Treatment Zhenjiang City, Zhenjiang, Jiangsu, Peoples R China.;Jiangsu Univ, Affiliated Peoples Hosp, Dept Hematol, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.;
[8]Jiangsu Univ, Affiliated Peoples Hosp, Lab Ctr, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.;Jiangsu Univ, Key Lab Precis Diag & Treatment Zhenjiang City, Zhenjiang, Jiangsu, Peoples R China.;
[9]Jiangsu Univ, Affiliated Peoples Hosp, Lab Ctr, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.;Jiangsu Univ, Key Lab Precis Diag & Treatment Zhenjiang City, Zhenjiang, Jiangsu, Peoples R China.;
[10]Jiangsu Univ, Key Lab Precis Diag & Treatment Zhenjiang City, Zhenjiang, Jiangsu, Peoples R China.;Jiangsu Univ, Affiliated Peoples Hosp, Dept Hematol, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.;
通讯作者:Lin, J (reprint author), Jiangsu Univ, Affiliated Peoples Hosp, Lab Ctr, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.; Qian, J (reprint author), Jiangsu Univ, Affiliated Peoples Hosp, Dept Hematol, 8 Dianli Rd, Zhenjiang 212002, Jiangsu, Peoples R China.
年:2017
期刊名称:ONCOTARGETS AND THERAPY影响因子和分区
卷:10
页码范围:3635-3644
增刊:正刊
收录情况:SCI(E)(WOS:000405948900001)  
语言:外文
ISSN:1178-6930
人气指数:50
浏览次数:50
基金:National Natural Science Foundation of China [81270630]; Special Funds of "Ke Jiao Qiang Wei" Project of Jiangsu Province [2015-WSN-115]; 333 Project of Jiangsu Province; China Postdoctoral Science Foundation [2016M601748]; Social Development Foundation of Zhenjiang [SH2015058, SH2016045, SH2016046]; Social Development Foundation of Kunshan [KS1624]; Key Medical Talent Program of Zhenjiang City; Six Talent Peaks Project in Jiangsu Province [2015-WSN-115]
关键词:SFRPs; methylation; RQ-MSP; non-M3 AML; prognosis
摘要:
Objective: Secreted frizzled-related proteins (SFRPs) as Wnt signaling antagonists have been found to be dysregulated by promoter hypermethylation in several cancers including acute myeloid leukemia (AML). This study aimed to investigate the methylated status of SFRPs promoter region and its clinical relevance in Chinese non-M3 AML patients. Methods: SFRPs methylation in 139 primary non-M3 AML patients was determined using methylation-specific real-time quantitative polymerase chain reaction. ...More
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