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An Epitope-Imprinted Biointerface with Dynamic Bioactivity for Modulating Cell-Biomaterial Interactions
文献类型:期刊
作者:Pan, Guoqing[1]  Shinde, Sudhirkumar[2]  Yeung, Sing Yee[3]  Jakstaite, Migle[4]  Li, Qianjin[5]  Wingren, Anette Gjorloff[6]  Sellergren, Borje[7]  
机构:[1]Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, SE-20506 Malmo, Sweden.;Jiangsu Univ, Sch Mat Sci & Engn, Inst Adv Mat, Zhenjiang 212013, Jiangsu, Peoples R China.;
[2]Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, SE-20506 Malmo, Sweden.;
[3]Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, SE-20506 Malmo, Sweden.;
[4]Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, SE-20506 Malmo, Sweden.;
[5]Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, SE-20506 Malmo, Sweden.;
[6]Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, SE-20506 Malmo, Sweden.;
[7]Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, SE-20506 Malmo, Sweden.;
通讯作者:Pan, Guoqing;
年:2017
期刊名称:ANGEWANDTE CHEMIE-INTERNATIONAL EDITION影响因子和分区
卷:56
期:50
页码范围:15959-15963
增刊:正刊
收录情况:SCI(E)(WOS:000417200600028)  EI(20174204285010)  
所属部门:材料科学与工程学院(新材料研究院 绿色材料与冶金研究院)
重要成果类型:重要期刊
语言:外文
ISSN:1433-7851
被引频次:12
人气指数:1055
浏览次数:1055
基金:Marie Sklodowska-Curie Actions (H2020-MSCA-IF-EF) [658953]; National Natural Science Foundation of China [21574091]; Natural Science Foundation of Jiangsu Province [BK20160056]
关键词:cell adhesion; cell release; dynamic biointerfaces; epitopes; molecular imprinting
摘要:
In this study, an epitope-imprinting strategy was employed for the dynamic display of bioactive ligands on a material interface. An imprinted surface was initially designed to exhibit specific affinity towards a short peptide (i.e., the epitope). This surface was subsequently used to anchor an epitope-tagged cell-adhesive peptide ligand (RGD: Arg-Gly-Asp). Owing to reversible epitope-binding affinity, ligand presentation and thereby cell adhesion could be controlled. As compared to current strat ...More
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