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Molecular Signatures of Major Depression
文献类型:期刊
作者:Cai, Na[1]  Chang, Simon[2]  Li, Yihan[3]  Li, Qibin[4]  Hu, Jingchu[5]  Liang, Jieqin[6]  Song, Li[7]  Kretzschmar, Warren[8]  Gan, Xiangchao[9]  Nicod, Jerome[10]  Rivera, Margarita[11]  Deng, Hong[12]  Du, Bo[13]  Li, Keqing[14]  Sang, Wenhu[15]  Gao, Jingfang[16]  Gao, Shugui[17]  Ha, Baowei[18]  Ho, Hung-Yao[19]  Hu, Chunmei[20]  Hu, Jian[21]  Hu, Zhenfei[22]  Huang, Guoping[23]  Jiang, Guoqing[24]  Jiang, Tao[25]  Jin, Wei[26]  Li, Gongying[27]  Li, Kan[28]  Li, Yi[29]  Li, Yingrui[30]  Li, Youhui[31]  Lin, Yu-Ting[32]  Liu, Lanfen[33]  Liu, Tiebang[34]  Liu, Ying[35]  Liu, Yuan[36]  Lu, Yao[37]  Lv, Luxian[38]  Meng, Huaqing[39]  Qian, Puyi[40]  Sang, Hong[41]  Shen, Jianhua[42]  Shi, Jianguo[43]  Sun, Jing[44]  Tao, Ming[45]  Wang, Gang[46]  Wang, Guangbiao[47]  Wang, Jian[48]  Wang, Linmao[49]  Wang, Xueyi[50]  Wang, Xumei[51]  Yang, Huanming[52]  Yang, Lijun[53]  Yin, Ye[54]  Zhang, Jinbei[55]  Zhang, Kerang[56]  Sun, Ning[57]  Zhang, Wei[58]  Zhang, Xiuqing[59]  Zhang, Zhen[60]  Zhong, Hui[61]  Breen, Gerome[62]  Wang, Jun[63]  Marchini, Jonathan[64]  Chen, Yiping[65]  Xu, Qi[66]  Xu, Xun[67]  Mott, Richard[68]  Huang, Guo-Jen[69]  Kendler, Kenneth[70]  Flintl, Jonathan[71]  
机构:[1]Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, Oxon, England.;
[2]Chang Gung Univ, Coll Med, Dept & Grad Inst Biomed Sci, Taoyuan 33302, Taiwan.;
[3]Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, Oxon, England.;
[4]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[5]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[6]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[7]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[8]Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, Oxon, England.;
[9]Max Planck Inst Plant Breeding Res, Dept Comparat Dev Genet, D-50829 Cologne, Germany.;
[10]Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, Oxon, England.;
[11]Univ Granada, CIBERSAM, Ctr Invest Med Red Salud Mental, Granada, Spain.;Kings Coll London, Inst Psychiat, MRC SGDP Ctr, London SE5 8AF, England.,Kings Coll London, Inst Psychiat, Biomed Res Ctr Mental Hlth, Natl Inst Hlth Res, London SE5 8AF, England.;
[12]Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu 610000, Sichuan, Peoples R China.;
[13]Hebei Mental Hlth Ctr, Baoding 71000, Hebei, Peoples R China.;
[14]Hebei Mental Hlth Ctr, Baoding 71000, Hebei, Peoples R China.;
[15]Hebei Mental Hlth Ctr, Baoding 71000, Hebei, Peoples R China.;
[16]Zhejiang Tradit Chinese Med Hosp, Hangzhou 310000, Zhejiang, Peoples R China.;
[17]Ningbo Kang Ning Hosp, Ningbo 315000, Zhejiang, Peoples R China.;
[18]Liaocheng 4 Hosp, Liaocheng 252000, Shandong, Peoples R China.;
[19]Chang Gung Univ, Coll Med, Dept Med Biotechnol & Lab Sci, Taoyuan 33302, Taiwan.;
[20]3 Hosp Heilongjiang Prov, Beian 164000, Heilongjiang, Peoples R China.;
[21]Harbin Med Univ, Haerbin 150000, Heilongjiang, Peoples R China.;
[22]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[23]Sichuan Mental Hlth Ctr, Mianyang 621000, Sichuan, Peoples R China.;
[24]Chongqing Mental Hlth Ctr, Chongqing 404100, Peoples R China.;
[25]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[26]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[27]Jining Med Coll, Mental Hlth Inst, Jining 272000, Shandong, Peoples R China.;
[28]Mental Hosp Jiangxi Prov, Nanchang 330000, Jiangxi, Peoples R China.;
[29]Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, Oxon, England.;BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;Wuhan Mental Hlth Ctr, Wuhan 430000, Hubei, Peoples R China.;
[30]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[31]Zhengzhou Univ, Hosp 1, Zhengzhou 450000, Henan, Peoples R China.;
[32]Chang Gung Univ, Coll Med, Grad Inst Biomed Sci, Taoyuan 33302, Taiwan.;
[33]Shandong Mental Hlth Ctr, Jinan 250000, Shandong, Peoples R China.;
[34]Kangning Hosp, Shenzhen Key Lab Psychol Healthcare, Shenzhen 518000, Guangdong, Peoples R China.;
[35]China Med Univ, Hosp 1, Shenyang 110001, Liaoning, Peoples R China.;
[36]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[37]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[38]Psychiat Hosp Henan Prov, Xinxiang 453000, Henan, Peoples R China.;
[39]Chongqing Med Univ, Hosp 1, Chongqing 400016, Peoples R China.;
[40]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[41]Changchun Mental Hosp, Changchun 130000, Jilin, Peoples R China.;
[42]Tianjin Anding Hosp, Tianjin 300000, Peoples R China.;
[43]Xian Mental Hlth Ctr, Xian 710000, Shaanxi, Peoples R China.;
[44]Nanjing Med Univ, Brain Hosp, Nanjing 210000, Jiangsu, Peoples R China.;
[45]Zhejiang Chinese Med Univ, Affiliated Hosp 2, Hangzhou 310000, Zhejiang, Peoples R China.;
[46]Capital Univ Med Sci, Beijing Anding Hosp, Beijing 100000, Peoples R China.;
[47]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[48]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[49]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[50]Hebei Med Univ, Hosp 1, Shijiazhuang 50000, Hebei, Peoples R China.;
[51]China Med Univ, ShengJing Hosp, Shenyang 110001, Liaoning, Peoples R China.;
[52]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[53]Jilin Brain Hosp, Siping 136000, Jilin, Peoples R China.;
[54]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[55]Sun Yat Sen Univ, Hosp 3, Guangzhou 510000, Guangdong, Peoples R China.;
[56]Shanxi Med Univ, Hosp 1, Taiyuan 30000, Shanxi, Peoples R China.;
[57]Shanxi Med Univ, Hosp 1, Taiyuan 30000, Shanxi, Peoples R China.;
[58]Daqing 3 Hosp Heilongjiang Prov, Daqing 163000, Heilongjiang, Peoples R China.;
[59]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[60]Jiangsu Univ, Hosp 4, Zhenjiang 212000, Jiangsu, Peoples R China.;
[61]Anhui Mental Hlth Ctr, Hefei 230000, Anhui, Peoples R China.;
[62]Kings Coll London, Inst Psychiat, MRC SGDP Ctr, London SE5 8AF, England.,Kings Coll London, Inst Psychiat, Biomed Res Ctr Mental Hlth, Natl Inst Hlth Res, London SE5 8AF, England.;
[63]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;Univ Copenhagen, Dept Biol, DK-2200 Copenhagen, Denmark.,Macau Univ Sci & Technol, Taipa 999078, Macau, Peoples R China.,King Abdulaziz Univ, Princess Al Jawhara Ctr Excellence Res Hereditary, Jeddah 21589, Saudi Arabia.;
[64]Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, Oxon, England.;Univ Oxford, Dept Stat, Oxford OX1 3TG, Oxon, England.;
[65]Univ Oxford, CTSU, Oxford OX3 7LF, Oxon, England.;
[66]Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 10005, Peoples R China.,Chinese Acad Med Sci, Neurosci Ctr, Beijing 10005, Peoples R China.,Peking Union Med Coll, Beijing 10005, Peoples R China.;
[67]BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.;
[68]Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, Oxon, England.;
[69]Chang Gung Univ, Coll Med, Dept & Grad Inst Biomed Sci, Taoyuan 33302, Taiwan.;
[70]Virginia Commonwealth Univ, Dept Psychiat MCV, Richmond, VA 23298 USA.;
[71]Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, Oxon, England.;E China Normal Univ, Shanghai 200062, Peoples R China.;
通讯作者:Flintl, J (reprint author), Univ Oxford, Wellcome Trust Ctr Human Genet, Roosevelt Dr, Oxford OX3 7BN, Oxon, England.
年:2015
期刊名称:CURRENT BIOLOGY影响因子和分区
卷:25
期:9
页码范围:1146-1156
增刊:正刊
学科:生物学和生物化学
收录情况:SCI(E)(WOS:000353999000021)  PubMed(25913401)  ESI高被引论文(WOS:000353999000021)  
重要成果类型:ESI高被引
语言:外文
ISSN:0960-9822
被引频次:80
人气指数:2928
浏览次数:2924
基金:Wellcome Trust [WT090532/Z/09/Z, WT083573/Z/07/Z, WT089269/Z/09/Z, WT097307]; Agency of Science, Technology and Research (A*STAR) Graduate Academy; National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
摘要:
Adversity, particularly in early life, can cause illness. Clues to the responsible mechanisms may lie with the discovery of molecular signatures of stress, some of which include alterations to an individual's somatic genome. Here, using genome sequences from 11,670 women, we observed a highly significant association between a stress-related disease, major depression, and the amount of mtDNA (p = 9.00 x 10(-42), odds ratio 1.33 [95% confidence interval [CI] = 1.29-1.37]) and telomere length (p = ...More
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